Dendritic Cell Reprogramming by Endogenously Produced Lactic Acid

  title={Dendritic Cell Reprogramming by Endogenously Produced Lactic Acid},
  author={Aikaterini Nasi and T{\"u}nde Fekete and Akilan Krishnamurthy and Stuart G. Snowden and Eva Rajnavölgyi and Anca Catrina and Craig E. Wheelock and Nancy Vivar and Bence R{\'e}thi},
  journal={The Journal of Immunology},
  pages={3090 - 3099}
The demand for controlling T cell responses via dendritic cell (DC) vaccines initiated a quest for reliable and feasible DC modulatory strategies that would facilitate cytotoxicity against tumors or tolerance in autoimmunity. We studied endogenous mechanisms in developing monocyte-derived DCs (MoDCs) that can induce inflammatory or suppressor programs during differentiation, and we identified a powerful autocrine pathway that, in a cell concentration–dependent manner, strongly interferes with… 

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