Dendritic Cell Differentiation Induced by a Self-Peptide Derived from Apolipoprotein E1

@article{Stephens2008DendriticCD,
  title={Dendritic Cell Differentiation Induced by a Self-Peptide Derived from Apolipoprotein E1},
  author={Tracey A. Stephens and Enayat Nikoopour and Beverly J Rider and Matilde Le{\'o}n-Ponte and Thu A. Chau and Sebastian A Mikolajczak and Pratibha Chaturvedi and Edwin Lee-Chan and Richard A. Flavell and S. M. Mansour Haeryfar and Joaqu{\'i}n Madrenas and Bhagirath Singh},
  journal={The Journal of Immunology},
  year={2008},
  volume={181},
  pages={6859 - 6871}
}
Dendritic cells (DCs) are professional APCs and potent stimulators of naive T cells. Since DCs have the ability to immunize or tolerize T cells they are unique candidates for use in immunotherapy. Our laboratory has discovered that a naturally processed self-peptide from apolipoprotein E, Ep1.B, induces DC-like morphology and surface marker expression in a murine monocytic cell line (PU5-1.8), human monocytic cell line (U937), murine splenocytes, and human peripheral blood monocytes. Microscopy… 
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