Dendritic Cell-Based Immunotherapy for Glioma: Multiple Regimens and Implications in Clinical Trials

  title={Dendritic Cell-Based Immunotherapy for Glioma: Multiple Regimens and Implications in Clinical Trials},
  author={Yohei Mineharu and Maria G Castro and Pedro R Lowenstein and Nobuyuki Sakai and Susumu Miyamoto},
  booktitle={Neurologia medico-chirurgica},
High grade glioma is a highly invasive brain tumor and recurrence is almost inevitable, even after radical resection of the tumor mass. Cytotoxic immune responses and immunological memory induced by immunotherapy might prevent tumor recurrence. Dendritic cells (DCs) are professional antigen-presenting cells of the innate immune system with the potential to generate robust antigen-specific T cell immune responses. DC-based immunotherapeutic strategies have been intensively studied in both… CONTINUE READING


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