Dendritic BC200 RNA in aging and in Alzheimer's disease.

  title={Dendritic BC200 RNA in aging and in Alzheimer's disease.},
  author={El Mus and Patrick R. Hof and Henri Tiedge},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 25},
Small untranslated BC1 and BC200 RNAs are translational regulators that are selectively targeted to somatodendritic domains of neurons. They are thought to operate as modulators of local protein synthesis in postsynaptic dendritic microdomains, in a capacity in which they would contribute to the maintenance of long-term synaptic plasticity. Because plasticity failure has been proposed to be a starting point for the neurodegenerative changes that are seen in Alzheimer's disease (AD), we asked… CONTINUE READING

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