Dendrite cell-T cell mixtures, isolated from the skin and mucosae of macaques, support the replication of SIV.

@article{Pope1997DendriteCC,
  title={Dendrite cell-T cell mixtures, isolated from the skin and mucosae of macaques, support the replication of SIV.},
  author={M. Mistrot Pope and David F. Elmore and David Seng Poh Ho and Preston A. Marx},
  journal={AIDS research and human retroviruses},
  year={1997},
  volume={13 10},
  pages={
          819-27
        }
}
Previous studies have shown that HIV-1 exploits dendritic cells (DCs) to replicate and spread among CD4+ T cells. The DCs within mucosal surfaces may be especially important, but these are more difficult to access. To study more extensively the properties of DCs and other leukocytes from skin and different mucosae, DCs were isolated from uninfected macaques and their sensitivity assessed to infection with SIV in vitro. Dendritic cells and T cells readily emigrated from organ cultures of macaque… CONTINUE READING
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