Dendrite and dendritic spine alterations in Alzheimer models.

  title={Dendrite and dendritic spine alterations in Alzheimer models.},
  author={Donna L Moolman and Ottavio V. Vitolo and Jean Paul G. Vonsattel and Michael L Shelanski},
  journal={Journal of neurocytology},
  volume={33 3},
Synaptic damage and loss are factors that affect the degree of dementia experienced in Alzheimer disease (AD) patients. Multicolor DiOlistic labeling of the hippocampus has been undertaken which allows the full dendritic arbor of targeted neurons to be imaged. Using this labeling technique the neuronal morphology of two transgenic mouse lines (J20 and APP/PS1) expressing mutant forms of the Amyloid Precursor Protein (APP), at various ages, have been visualized and compared to Wild Type (WT… CONTINUE READING
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