Dendrimers as a carrier for pulmonary delivery of enoxaparin, a low-molecular weight heparin.

@article{Bai2007DendrimersAA,
  title={Dendrimers as a carrier for pulmonary delivery of enoxaparin, a low-molecular weight heparin.},
  author={Shuhua Bai and Chandan Thomas and Fakhrul Ahsan},
  journal={Journal of pharmaceutical sciences},
  year={2007},
  volume={96 8},
  pages={2090-106}
}
This study was designed to test the hypothesis that positively charged dendrimers form a complex with enoxaparin, a low-molecular weight heparin (LMWH), and that the resulting drug-dendrimer complex is effective in preventing deep vein thrombosis after pulmonary administration. Fourier Transform Infrared (FTIR) spectroscopy and the azure A assay were used to evaluate interactions between dendrimers and enoxaparin. The efficacy of polyamidoamine (PAMAM) dendrimers in enhancing pulmonary… CONTINUE READING

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