Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model.

@article{Kannan2012DendrimerbasedPT,
  title={Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model.},
  author={Sujatha Kannan and Hui Chao Dai and Raghavendra Swamy Navath and Bindu Balakrishnan and Amar Jyoti and James Janisse and Roberto Romero and Rangaramanujam M Kannan},
  journal={Science translational medicine},
  year={2012},
  volume={4 130},
  pages={
          130ra46
        }
}
Cerebral palsy (CP) is a chronic childhood disorder with no effective cure. Neuroinflammation, caused by activated microglia and astrocytes, plays a key role in the pathogenesis of CP and disorders such as Alzheimer's disease and multiple sclerosis. Targeting neuroinflammation can be a potent therapeutic strategy. However, delivering drugs across the blood-brain barrier to the target cells for treating diffuse brain injury is a major challenge. We show that systemically administered… CONTINUE READING

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