Denaturation and renaturation of a beta-1,6;1,3-glucan, lentinan, associated with expression of T-cell-mediated responses.

@article{Maeda1988DenaturationAR,
  title={Denaturation and renaturation of a beta-1,6;1,3-glucan, lentinan, associated with expression of T-cell-mediated responses.},
  author={Yukiko Y. Maeda and Shinichi Watanabe and Charles Chihara and Makoto Rokutanda},
  journal={Cancer research},
  year={1988},
  volume={48 3},
  pages={671-5}
}
Correlation between the higher structure and biological functions of lentinan, a beta-1,6;1,3-glucan capable of potentiating T- and non-T-cell-mediated responses, were investigated by measurements of optical rotation and some biological responses. The addition of urea or dimethyl sulfoxide decreased specific rotation at 589 nm, [alpha]D, of lentinan in a concentration-dependent manner and the removal of these denaturants resulted in the recovery of [alpha]D values. Measurements of optical… CONTINUE READING

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