Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways

  title={Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways},
  author={Ki-Suk Kim and Josephine M. Egan and Hyeung-Jin Jang},
This study was designed to ascertain whether human enteroendocrine cells express bitter taste receptors, and whether activation of these receptors with bitter-tasting ligands induces secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). We used human enteroendocrine NCI-H716 cells, isolated duodenal segments from mice, and whole mice as our experimental systems for investigating stimuli and mechanisms underlying GLP-1- and PYY-stimulated release. We measured hormone levels by ELISA… CONTINUE READING
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