Demyelination in vitro. Absorption studies demonstrate that galactocerebroside is a major target.

@article{Raine1981DemyelinationIV,
  title={Demyelination in vitro. Absorption studies demonstrate that galactocerebroside is a major target.},
  author={Cedric S Raine and Anne B. Johnson and Dennis M. Marcus and Ayako Suzuki and Murray B. Bornstein},
  journal={Journal of the neurological sciences},
  year={1981},
  volume={52 1},
  pages={117-31}
}
Myelinated cultures of mouse spinal cord have been exposed to sera raised in rabbits against whole white matter (anti-WM), myelin basic protein (anti-MBP) and galactocerebroside (anti-GC), the major glycolipid of CNS myelin, to determine which factor in central nervous system (CNS) tissue in vitro is the target of serum demyelinating and myelin swelling antibodies. The sera were tested by radioimmunoassay for activity against MBP and against GC and were also specifically absorbed with MBP, GC… CONTINUE READING