Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients.

@article{Dutta2011DemyelinationCS,
  title={Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients.},
  author={Ranjan Dutta and Ansi Chang and Mary Kathryn Doud and Grahame J Kidd and Michael V Ribaudo and Elizabeth Anne Young and Robert J Fox and Susan M. Staugaitis and Bruce D Trapp},
  journal={Annals of neurology},
  year={2011},
  volume={69 3},
  pages={445-54}
}
OBJECTIVE Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the human central nervous system. Although the clinical impact of gray matter pathology in MS brains is unknown, 30 to 40% of MS patients demonstrate memory impairment. The molecular basis of this memory dysfunction has not yet been investigated in MS patients. METHODS To investigate possible mechanisms of memory impairment in MS patients, we compared morphological and molecular changes in myelinated and… CONTINUE READING