Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication

@article{Steelman2012DemyelinationAR,
  title={Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication},
  author={Andrew J. Steelman and Jeffrey P. Thompson and J Li},
  journal={Neuroscience Research},
  year={2012},
  volume={72},
  pages={32-42}
}
Multiple sclerosis is a chronic demyelinating disease of the central nervous system. Spontaneous remyelination during early disease stages is thought to preserve and partially restore function. However, this process ceases in later stages despite the presence of pre-oligodendrocytes. Cuprizone-induced demyelination is a useful model with which to study the remyelination process. Previous studies have demonstrated heterogeneities in demyelination in individual animals. Here we investigated… CONTINUE READING

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