Demyelinating and Neurologic Events Reported in Association With Tumor Necrosis Factor a Antagonism By What Mechanisms Could Tumor Necrosis Factor a Antagonists Improve Rheumatoid Arthritis but Exacerbate Multiple Sclerosis?


Tumor necrosis factor a (TNFa) inhibition is the most significant advancement in the treatment of rheumatoid arthritis (RA) since the adoption of methotrexate in the 1980s (1,2). As TNFa antagonists have become increasingly utilized, both as monotherapy and in combination with traditional disease-modifying antirheumatic drugs, there have been a number of… (More)


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