Demonstration of virus-specific CD8+ memory T cells in measles-seropositive individuals by in vitro peptide stimulation.

Abstract

CD8+ cytotoxic T lymphocytes (CTL) in measles virus infection have been difficult to investigate due to the strong immunosuppressive effects exhibited by infectious measles virus in vitro. In order to circumvent immunosuppression we used predicted peptide epitopes to induce measles virus-specific CTL. This was done by screening the structural proteins of… (More)

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