Demonstration of proton-transfer reaction time-of-flight mass spectrometry for real-time analysis of trace volatile organic compounds.

Abstract

A proton-transfer reaction mass spectrometer based on time-of-flight mass spectrometry is described. This instrument couples a radioactive ion source and drift tube with a reflectron time-of-flight mass spectrometer. Volatile organic compounds in the gas phase with concentrations at the parts per billion by volume level can be detected in a matter of seconds, and crucially, the multichannel data acquisition in TOF-MS means that this detection sensitivity is available in all mass channels simultaneously. The typical mass resolution (m/Deltam) is in excess of 1000. The performance of the instrument is demonstrated using urban air measurements and a linear response/calibration test.

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@article{Blake2004DemonstrationOP, title={Demonstration of proton-transfer reaction time-of-flight mass spectrometry for real-time analysis of trace volatile organic compounds.}, author={Robert S. Blake and Christopher E. Whyte and Ceri O Hughes and Andrew M Ellis and Paul S Monks}, journal={Analytical chemistry}, year={2004}, volume={76 13}, pages={3841-5} }