Demonstration of organ specific antibodies against heart mitochondria (anti-M7) in sera from patients with some forms of heart diseases.

@article{Klein1984DemonstrationOO,
  title={Demonstration of organ specific antibodies against heart mitochondria (anti-M7) in sera from patients with some forms of heart diseases.},
  author={Reinhild Klein and Bernhard Maisch and Kurt Kochsiek and Peter Alfred Berg},
  journal={Clinical and experimental immunology},
  year={1984},
  volume={58 2},
  pages={283-92}
}
Using submitochondrial particles (SMP) from beef heart, pig kidney and rat liver in the ELISA, we detected partial organ specific anti-mitochondrial antibodies (AMA) against heart and kidney SMP in sera from patients with different forms of cardiomyopathies. Serum samples from 50 of 159 patients with congestive or hypertrophic cardiomyopathy (31%) and from two of 15 patients with acute myocarditis (13%) were AMA positive. These AMA could be clearly differentiated from other known AMA (anti-M1… CONTINUE READING

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