Demonstration of neutrophil chemotactic activity in the sputum of cystic fibrosis patients with Pseudomonas aeruginosa infection.

@article{Kharazmi1986DemonstrationON,
  title={Demonstration of neutrophil chemotactic activity in the sputum of cystic fibrosis patients with Pseudomonas aeruginosa infection.},
  author={Arsalan Kharazmi and Peter Oluf Schi\otz and Niels H\oiby and Leif Baek and G. N. Doering},
  journal={European journal of clinical investigation},
  year={1986},
  volume={16 2},
  pages={143-8}
}
The pathogenesis of tissue damage in the lungs of cystic fibrosis patients with chronic P. aeruginosa infection is quite complex and not well understood. Inflammatory cells, particularly neutrophils, are accumulated in the damaged tissues and in the sputum. This study demonstrates the presence of a heat-stable neutrophil chemotactic factor(s) in the sputum of CF patients. The chemotactic activity seems to be associated with the endotoxin present in the sputum. Chemotaxis of sol phase sputum was… CONTINUE READING