Demonstration of multiple phenotypic diversity in a murine melanoma of recent origin.

@article{Fidler1981DemonstrationOM,
  title={Demonstration of multiple phenotypic diversity in a murine melanoma of recent origin.},
  author={Isaiah Josh Fidler and Eilene Gruys and Maria A. Cifone and Z L Barnes and Corazon D. Bucana},
  journal={Journal of the National Cancer Institute},
  year={1981},
  volume={67 4},
  pages={947-56}
}
The purpose of these studies was to examine whether the metastatic heterogeneity that is frequently found in serially transplanted neoplasms could be observed in a murine melanoma of recent origin. The primary K-1735 melanoma that arose in an inbred C3H/HeN murine mammary tumor virus-negative (C3H-) mouse was transplanted once into an immunosuppressed recipient and then established in culture. Cells from the fifth in vitro passage were used to produce clones. The parent K-1735 and 22 cloned… CONTINUE READING