Demonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activity.

@article{Manya2004DemonstrationOM,
  title={Demonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activity.},
  author={Hiroshi Manya and Atsuro Chiba and Aruto Yoshida and Xiaohui Wang and Yasunori Chiba and Yoshifumi Jigami and Richard U. Margolis and Takenori Endo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 2},
  pages={
          500-5
        }
}
Defects in O-mannosylation of alpha-dystroglycan are thought to cause certain types of congenital muscular dystrophies with neuronal migration disorders. Among these muscular dystrophies, Walker-Warburg syndrome is caused by mutations in the gene encoding putative protein O-mannosyltransferase 1 (POMT1), which is homologous to yeast protein O-mannosyltransferases. However, there is no evidence that POMT1 has enzymatic activity. In this study, we first developed a method to detect protein O… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 146 CITATIONS

Similar Papers

Loading similar papers…