Demonstration of improvements to the bioluminescence resonance energy transfer (BRET) technology for the monitoring of G protein-coupled receptors in live cells.

@article{Kocan2008DemonstrationOI,
  title={Demonstration of improvements to the bioluminescence resonance energy transfer (BRET) technology for the monitoring of G protein-coupled receptors in live cells.},
  author={Martina Kocan and Heng B. See and Ruth M. Seeber and Karin Ann Eidne and Kevin Donald George Pfleger},
  journal={Journal of biomolecular screening},
  year={2008},
  volume={13 9},
  pages={888-98}
}
The bioluminescence resonance energy transfer (BRET) technique has become extremely popular for studying protein-protein interactions in living cells and real time. Of particular interest is the ability to monitor interactions between G protein-coupled receptors, such as the thyrotropin-releasing hormone receptor (TRHR), and proteins critical for regulating their function, such as beta-arrestin. Using TRHR/beta-arrestin interactions, we have demonstrated improvements to all 3 generations of… CONTINUE READING
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