Demonstration of hypnozoites in sporozoite-transmitted Plasmodium vivax infection.

  title={Demonstration of hypnozoites in sporozoite-transmitted Plasmodium vivax infection.},
  author={W A Krotoski and William E. Collins and Robert S. Bray and P. C. G. Garnham and Frank B. Cogswell and Robert W. Gwadz and Robert Killick-Kendrick and Robert H. Wolf and Robert E Sinden and L C Koontz and P S Stanfill},
  journal={The American journal of tropical medicine and hygiene},
  volume={31 6},
Hypnozoites of two strains of the human relapsing malaria parasite, Plasmodium vivax, have been detected among maturing 7- and 10-day pre-erythrocytic schizonts in liver biopsies of chimpanzees infected by intravenous inoculation of sporozoites obtained from dissected salivary glands of heavily infected anopheline mosquitoes. As in the simian relapsing species, P. cynomolgi, the hypnozoites of P. vivax at 7 and 10 days are uninucleate forms of approximately 4-5 micrometers diameter, lying… CONTINUE READING
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