Demonstration of human Borna disease virus RNA in human peripheral blood mononuclear cells.

@article{Kishi1995DemonstrationOH,
  title={Demonstration of human Borna disease virus RNA in human peripheral blood mononuclear cells.},
  author={Masahiko Kishi and Takaaki Nakaya and Yurie Nakamura and Qun Zhong and Kazuhiko Ikeda and M Senjo and Mitsuaki Kakinuma and Seishi Kato and Kazuyoshi Ikuta},
  journal={FEBS letters},
  year={1995},
  volume={364 3},
  pages={
          293-7
        }
}
BDV naturally infects horses and sheep, and causes sporadic neurological disease. Serological evidence suggests an association of BDV, or a related virus, with specific psychiatric diseases in humans. Here, by using a nested RT-PCR technique, we demonstrate that human BDV RNA is present in the PBMC of psychiatric patients. In an examination of a total of 60 patients from 5 wards of a hospital in Japan, the detection rate differed within each ward, ranging from 8% to > 50% (37% on the average… CONTINUE READING

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