Demonstration of electrogenic Na+-dependent D-glucose transport in intestinal brush border membranes.

@article{Murer1974DemonstrationOE,
  title={Demonstration of electrogenic Na+-dependent D-glucose transport in intestinal brush border membranes.},
  author={Heini Murer and Ulrich Hopfer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1974},
  volume={71 2},
  pages={484-8}
}
Na(+)-coupled D-glucose transport was studied in isolated membrane vesicles from intestinal brush borders. Concentration gradients of SCN(-), K(+), and H(+) were established between the intravesicular solution and the incubation medium and their influence on D-glucose uptake from the medium was measured. A gradient (medium > vesicle) of NaSCN, but not of KSCN, produced a transient overshoot of D-glucose uptake above the equilibrium level. Similarly, an increase of the membrane conductance with… CONTINUE READING
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