Demonstration of docosahexaenoic acid as a bioavailability enhancer for CYP3A substrates: in vitro and in vivo evidence using cyclosporin in rats.

@article{Hirunpanich2006DemonstrationOD,
  title={Demonstration of docosahexaenoic acid as a bioavailability enhancer for CYP3A substrates: in vitro and in vivo evidence using cyclosporin in rats.},
  author={Vilasinee Hirunpanich and Jun Katagi and Benjabhorn Sethabouppha and Hitoshi Sato},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2006},
  volume={34 2},
  pages={305-10}
}
To investigate the pharmacokinetic interaction between cyclosporin A (CsA) and docosahexaenoic acid (DHA) in vivo, 5 mg/kg CsA was orally or intravenously coadministered with DHA (50-200 microg/kg) to rats. The effect of DHA on CYP3A activity was determined using rat liver microsomes in vitro. Moreover, the effect of DHA on P-glycoprotein (P-gp) function was examined using cultured Caco-2 cells in vitro. After oral coadministration of CsA with 100 microg/kg and 200 microg/kg DHA… CONTINUE READING

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