Demonstration of delayed recovery from fatiguing exercise in chronic fatigue syndrome

@article{Paul1999DemonstrationOD,
  title={Demonstration of delayed recovery from fatiguing exercise in chronic fatigue syndrome},
  author={Lorna Paul and Les Wood and Wilhelmina M. H. Behan and William M. Maclaren},
  journal={European Journal of Neurology},
  year={1999},
  volume={6}
}
Patients with the chronic fatigue syndrome (CFS) complain consistently of delay in recovery of peripheral muscle function after exercise. The purpose of this study was to try to confirm this observation. A fatiguing exercise test was carried out on the quadriceps muscle group of ten patients and ten control subjects. The test consisted of 18 maximum voluntary contractions (MVCs) with a 50% duty cycle (10 s contraction, 10 s rest), and the force generated by each contraction was recorded using a… 
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References

SHOWING 1-10 OF 26 REFERENCES
Exercise performance and fatiguability in patients with chronic fatigue syndrome.
TLDR
Raised perceived exertion scores during exercise suggest that central factors are limiting exercise capacity in patients with chronic fatigue syndrome.
Muscle strength, endurance and recovery in the post-infection fatigue syndrome.
TLDR
The prominent subjective complaint of muscle fatigue in patients with post-infection fatigue syndrome contrasts with the relatively normal behaviour of their muscles during a controlled test of fatigue.
Central basis of muscle fatigue in chronic fatigue syndrome
TLDR
Patients with CFS have normal fatigability and metabolism at both the intracellular and systemic levels, normal muscle membrane function and excitation-contraction coupling, and an inability to fully activate skeletal muscle during intense, sustained exercise.
Normal muscle strength and fatigability in patients with effort syndromes.
TLDR
Patients with excess fatigue were neither weaker nor more fatigable than controls; thus the excess fatigue experienced by the patients was not due to a defect of the contractile apparatus, and the increased perception of effort must be due to impairment of central rather than peripheral mechanisms.
Decreased postexercise facilitation of motor evoked potentials in patients with chronic fatigue syndrome or depression
TLDR
It is concluded that postexercise cortical excitability is significantly reduced in patients with chronic fatigue syndrome and in depressed patients compared with that of normal subjects.
Muscle histopathology and physiology in chronic fatigue syndrome.
TLDR
There was no consistent correlation between symptoms and changes in fibre type prevalence, fibre size, degenerative or regenerative features, glycogen depletion, or mitochondrial abnormalities, and it is clear that CFS is not a myopathy.
Muscle performance, voluntary activation, twitch properties and perceived effort in normal subjects and patients with the chronic fatigue syndrome.
TLDR
Findings support the concept that neither poor motivation, nor muscle contractile failure is important in the pathogenesis of 'fatigue' in patients with the chronic fatigue syndrome.
Aerobic work capacity in patients with chronic fatigue syndrome.
TLDR
Patients with the chronic fatigue syndrome have reduced aerobic work capacity compared with normal subjects and patients with the irritable bowel syndrome and have an altered perception of their degree of exertion and their premorbid level of physical activity.
Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy.
TLDR
Patients with CFS and normal control subjects have similar skeletal muscle metabolic patterns during dynamic exercise and reach similar clinical and metabolic end points, however, CFS patients reach exhaustion much more rapidly than normal subjects, at which point they also have relatively reduced intracellular concentrations of ATP.
Reduced oxidative muscle metabolism in chronic fatigue syndrome
TLDR
In conclusion, oxidative metabolism is reduced in CFS patients compared to sedentary controls, and a single bout of strenuous exercise did not cause a further reduction in oxidative metabolism, or alter resting Pi/PCr ratios.
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