Demonstration of bactericidal and synergistic activity of quercetin with meropenem among pathogenic carbapenem resistant Escherichia coli and Klebsiella pneumoniae.

@article{Pal2020DemonstrationOB,
  title={Demonstration of bactericidal and synergistic activity of quercetin with meropenem among pathogenic carbapenem resistant Escherichia coli and Klebsiella pneumoniae.},
  author={Arijit Pal and Anusri Tripathi},
  journal={Microbial pathogenesis},
  year={2020},
  pages={
          104120
        }
}

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References

SHOWING 1-10 OF 32 REFERENCES
The synergy and mode of action of quercetin plus amoxicillin against amoxicillin-resistant Staphylococcus epidermidis
TLDR
These findings are the first report that quercetin has the synergistic effect with amoxicillin against ARSE via four modes of actions, inhibit peptidoglycan synthesis and β-lactamases activity, increase CM permeability and protein amide I and II but decrease fatty acid in bacterial cells.
In vitro characterization and inhibition of the interaction between ciprofloxacin and berberine against multidrug-resistant Klebsiella pneumoniae
TLDR
The in vitro antibacterial activities of ciprofloxacin in combination with berberine were evaluated and synergism was verified through a time-kill assay, which suggested that the synergistic antibacterial effect of the two-drug combination may be related to the high expression of the acrAB-tolC and acrR multidrug efflux pumps.
Synergistic effects of baicalein with cefotaxime against Klebsiella pneumoniae through inhibiting CTX-M-1 gene expression
TLDR
Baicalein exhibited synergistic activity when combined with cefotaxime against some of extended- spectrum β- lactamases positive K. pneumoniae strains by inhibiting CTX-M-1 mRNA expression, but no direct bactericidal or bacteriostatic activity was involved in the synergistic action.
Synergy and Mode of Action of Ceftazidime plus Quercetin or Luteolin on Streptococcus pyogenes
TLDR
Evidence is provided that the inhibitory mode of action of luteolin and quercetin may be mediated via three mechanisms: (1) inhibiting of peptidoglycan synthesis, (2) increasing CM permeability, and (3) decreasing nucleic acid but increasing the protein contents of bacterial cells.
Contribution of acrB upregulation & OmpC/Ompk36 loss over the presence of blaNDM towards carbapenem resistance development among pathogenic Escherichia coli & Klebsiella spp.
TLDR
These findings implied the major contribution of porin loss and/or efflux pump activation over the presence of ESBLs/carbapenemase-producing isolates in imparting carbapenems resistance in pathogenic bacteria.
Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro
TLDR
The identified synergistic combinations can be of potent therapeutic value against P. aeruginosa infections and have potential implications in delaying the development of resistance as the antibacterial effect is achieved with lower concentrations of both drugs (antibiotics and phytochemicals).
Antimicrobial activity of pomegranate fruit constituents against drug-resistant Mycobacterium tuberculosis and β-lactamase producing Klebsiella pneumoniae
TLDR
The pomegranate fruit peel and pure constituents were active against a broad panel of M. tuberculosis and β-lactamase producing K. pneumoniae isolates, and EGCG and quercetin exhibited higher antitubercular and antibacterial potencies than caffeic acid and ellagic acid.
Antibiotic additive and synergistic action of rutin, morin and quercetin against methicillin resistant Staphylococcus aureus
TLDR
The flavonoids when used in combination with antibiotics were found to increase each other activity against test bacteria and synergism was observed in a few cases.
Antimicrobial activity of two propolis samples against human Campylobacter jejuni.
TLDR
Propolis preparations could be used as support to traditional therapy for Campylobacter infection, especially when the antibiotic agents show no activity against this microorganism.
...
...