Demonstration of an early and a late phase of ischemic preconditioning in mice.

  title={Demonstration of an early and a late phase of ischemic preconditioning in mice.},
  author={Yuzhen Guo and Wen Jie Wu and Yumin Qiu and Xiufeng Tang and Zequan Yang and Reinhard Bolli},
  journal={The American journal of physiology},
  volume={275 4 Pt 2},
It is unknown whether ischemic preconditioning (PC; either early or late) occurs in the mouse. The goal of this study was to answer this question and to develop a reliable and physiologically relevant murine model of both early and late ischemic PC. A total of 201 mice were used. In nonpreconditioned open-chest animals subjected to 30 min of coronary occlusion followed by 24 h of reperfusion, infarct size (tetrazolium staining) averaged 52% of the region at risk. When the 30-min occlusion was… CONTINUE READING
97 Citations
57 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 97 extracted citations


Publications referenced by this paper.
Showing 1-10 of 57 references

Preconditioning during ischemia

  • M. V. Cohen, J. M. Downey
  • Cardiol. Rev
  • 1995
Highly Influential
6 Excerpts

The cardiovascular system. Normative biology, immunology, and husbandry

  • H. M. Kaplan, N. R. Brewer, W. H. Blair
  • The Mouse in Biomedical Research,
  • 1983
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…