Demonstration of an ATP-dependent, vanadate-sensitive endoprotease in the matrix of rat liver mitochondria.

@article{Desautels1982DemonstrationOA,
  title={Demonstration of an ATP-dependent, vanadate-sensitive endoprotease in the matrix of rat liver mitochondria.},
  author={Michel Desautels and Alfred L Goldberg},
  journal={The Journal of biological chemistry},
  year={1982},
  volume={257 19},
  pages={
          11673-9
        }
}
We have recently demonstrated that mammalian mitochondria contain an ATP-dependent, vanadate-sensitive pathway for the complete degradation of mitochondrial proteins. An ATP-dependent endoprotease active against [3H-methyZ]casein and [‘4C-methyZ]globin but not ‘261-insulin has been isolated from rat liver mitochondria by a combination of ion exchange chromatography and gel filtration. This protease is present in the mitochondrial matrix and is active only at alkaline pH. The enzyme has an… CONTINUE READING
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Symp • 1980