Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.

@article{Tsudo1986DemonstrationOA,
  title={Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.},
  author={Mitsuru Tsudo and Robert W. Kozak and Carolyn K. Goldman and Thomas A. Waldmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 24},
  pages={9694-8}
}
The interleukin 2 (IL-2) receptor system plays a key role in the T-cell immune response. Although IL-2 binding was reported to be restricted to the Tac peptide, we have identified an IL-2 binding peptide that does not react with anti-human IL-2 receptor monoclonal antibodies, including anti-Tac on MLA 144, a gibbon ape T-cell line. The MLA 144 cell line expressed 6800 IL-2 binding sites per cell with a low (Kd = 14 nM) affinity for human recombinant IL-2. Using cross-linking methodology, we… CONTINUE READING