Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements in normal and diabetic individuals.

@article{Cooper2005DemonstrationOA,
  title={Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements in normal and diabetic individuals.},
  author={Garth J S Cooper and Y Chan and Ajith Munasinghe Dissanayake and Fiona E Leahy and Geraldine F Keogh and Chris Frampton and Gregory David Gamble and Dianne H. Brunton and J. R. J. Baker and Sally D Poppitt},
  journal={Diabetes},
  year={2005},
  volume={54 5},
  pages={1468-76}
}
We recently showed that treatment with the Cu(II)-selective chelator, trientine, alleviates heart failure in diabetic rats, improves left ventricular hypertrophy in humans with type 2 diabetes, and increases urinary Cu excretion in both diabetic rats and humans compared with nondiabetic control subjects. In this study, we characterized the homeostasis of Cu and eight other nutritionally essential elements in diabetes under fully residential conditions in male subjects with type 2 diabetes and… CONTINUE READING

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