Demonstration of a Na+: Mg2+ exchange in human red cells by its sensitivity to tricyclic antidepressant drugs

@article{Fray1988DemonstrationOA,
  title={Demonstration of a Na+: Mg2+ exchange in human red cells by its sensitivity to tricyclic antidepressant drugs},
  author={J C F{\'e}ray and Ricardo Garay},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1988},
  volume={338},
  pages={332-337}
}
Iminodibenzyl-, iminostilbene-, dibenzocycloheptadiene-, dibenzooxepine- and dibenzothiepine-derivatives of tricyclic antidepressant drugs were able to inhibit Na+-stimulated Mg2+ efflux in human erythrocytes at concentrations of 10−5−10−3 mol/l. Tricyclic antidepressant drugs belonging to other chemical groups, non-tricyclic antidepressant drugs and phenothiazines were less potent inhibitors (IC50 of 10−4 mol/l or higher). Imipramine and dothiepine, the most potent compounds, inhibited the Mg… CONTINUE READING
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Interaction between the Na+-K + pump and Na+-Ca 2+ exchange in vascular smooth muscle cells: Inhibition by the amiloride analogue L-651525

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