Demonstration of Two Classes of Opiate Binding Sites in the Nervous Tissue of the Marine Mollusc Mytilus edulis

@inproceedings{RichardDemonstrationOT,
  title={Demonstration of Two Classes of Opiate Binding Sites in the Nervous Tissue of the Marine Mollusc Mytilus edulis},
  author={Richard and KreamS and Suzanne Zukint and George and {\vS}tefan}
}
[3)flEtorphine, ' " I-FK 33-824 (a highly potent en-kephalin derivative of enhanced stability), and '261-lev-allorphan bound stereospecifically, with high affinity, and reversibly to pedal ganglia membranes of the marine mollusc Mytilus edulis. Each ligand exhibited (by Scatchard analysis) noncooperative binding to a class of high affinity sites (& = 1 to 3 mi) and cooperative binding to a class of lower affinity sites (& = 6 to 11 m). Hill analyses of the cooperative site revealed Hill… CONTINUE READING

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