Demonstration of Skin Antibodies in Sera of Pemphigus Vulgaris Patients by Indirect Immunofluorescent Staining.∗

@article{Beutner1964DemonstrationOS,
  title={Demonstration of Skin Antibodies in Sera of Pemphigus Vulgaris Patients by Indirect Immunofluorescent Staining.∗},
  author={Ernst H. Beutner and Robert E. Jordon},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1964},
  volume={117},
  pages={505 - 510}
}
  • E. BeutnerR. Jordon
  • Published 1 November 1964
  • Medicine, Biology
  • Proceedings of the Society for Experimental Biology and Medicine
Summary 1. Eight of 13 sera from patients with pemphigus vulgaris were found to contain antibodies to a substance at the surface of the cells of stratified squamous epithelium, particularly in the stratum spinosum, as demonstrated by indirect immunofluores-cent (I.I.F.) staining. The reactions of 4 of these 8 sera were deemed to be weakly positive or doubtful while the remaining 4 sera yielded titers of 1:30 to 1:120 by I.I.F. staining. The reactive antigen was found only in stratified squamous… 

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AUTOANTIBODIES IN PEMPHIGUS VULGARIS: RESPONSE TO AN INTERCELLULAR SUBSTANCE OF EPIDERMIS.

Antibodies to an intercellular substance of stratified squamous epithelium were detected by indirect immunofluorescent (IF) staining in the sera of eight out of 16 patients with pemphigus vulgaris and by direct IF staining of biopsies, γglobulin was demonstrated in the inter cellular areas of the epidermis.

Anti-Intercellular Substance Antibodies: Presence in Serum Samples of 14 Patients Without Pemphigus

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Immunopathologic studies of experimental pemphigus-like autoantibodies and bullous-like lesions.

  • R. Ablin
  • Medicine, Biology
    The Journal of investigative dermatology
  • 1969
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AUTOANTIBODIES IN SOME BULLOUS DISEASES

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It is indicated that the autoantibody response in pemphigus vulgaris is heterogeneous, and in one patient the disease evolved from pure mucosal involvement associated with anti-desmoglein 3 antibodies to a disorder involving mucosas and skin.

Epidermal cytoplasmic antibodies

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Detection of class-specific antibodies of pemphigus vulgaris using a solid phase radioimmunoassay.

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Molecular mechanisms of pathogenesis.

Epidermal cytoplasmic antibodies. (Incidence and clinical significance).

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