Demonstration of Cu-Zn superoxide dismutase in rat liver peroxisomes. Biochemical and immunochemical evidence.

@article{Dhaunsi1992DemonstrationOC,
  title={Demonstration of Cu-Zn superoxide dismutase in rat liver peroxisomes. Biochemical and immunochemical evidence.},
  author={Gursev S Dhaunsi and Shweta Gulati and Avtar Kaur Singh and John K. Orak and Kohtaro Asayama and Inderjit Singh},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 10},
  pages={6870-3}
}
In this study, by using highly purified rat liver peroxisomes, we provide evidence from analytical cell fractionation, Western blot, and immunocytochemical analysis that Cu-Zn superoxide dismutase is present in animal peroxisomes. Treatment with ciprofibrate, a peroxisome proliferator, increased the peroxisomal superoxide dismutase activity by 3-fold with no effect on mitochondrial activity but a marked decrease in cytosolic superoxide dismutase activity, further supporting that besides… CONTINUE READING

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