Demonstration of C1q - binding to collagen - anticollagen immune complexes in synovial fluids of RA-patients.

@article{Menzel1982DemonstrationOC,
  title={Demonstration of C1q - binding to collagen - anticollagen immune complexes in synovial fluids of RA-patients.},
  author={Johannes Menzel and C A Steffen},
  journal={Zeitschrift fur Rheumatologie},
  year={1982},
  volume={41 2},
  pages={47-9}
}
Collagen-anticollagen immune complexes were demonstrated indirectly in RA synovial fluids by digestion with collagenase and subsequent antibody determination. Elimination of C1q was performed by affinity chromatography using an anti-C1q column. Binding of C1q to collagen-anticollagen complexes was proven by demonstrating that collagenase-caused liberation of collagen antibodies was abolished or distinctly reduced after passage through the anti-C1q column. Binding of C1q to collagen-anticollagen… CONTINUE READING

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Springer Berlin Heidelberg • 1992
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