Demonstration and functional analysis of IL-10 receptors in human epidermal cells: decreased expression in psoriatic skin, down-modulation by IL-8, and up-regulation by an antipsoriatic glucocorticosteroid in normal cultured keratinocytes.

@article{Michel1997DemonstrationAF,
  title={Demonstration and functional analysis of IL-10 receptors in human epidermal cells: decreased expression in psoriatic skin, down-modulation by IL-8, and up-regulation by an antipsoriatic glucocorticosteroid in normal cultured keratinocytes.},
  author={Guenter Michel and Alireza Mirmohammadsadegh and E. B. Olasz and B. Jarzebska-Deussen and A. M{\"u}schen and Lajos Kem{\'e}ny and Harry F Abts and Thomas Ruzicka},
  journal={Journal of immunology},
  year={1997},
  volume={159 12},
  pages={6291-7}
}
The chronic skin disease psoriasis is characterized by epidermal hyperproliferation and inflammation. The exact etiology of the disease is still unknown. At the molecular level, overexpression of growth factors and proinflammatory cytokines such as IL-8 and the corresponding receptor has been described in psoriatic plaques. On the other hand, the loss of inhibitory control mechanisms is involved in the pathogenesis of the disease, as exemplified by the reduced mRNA levels for the cell cycle… CONTINUE READING

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