Demonstration and characterization of the iron regulatory protein in human brain.

@article{Hu1996DemonstrationAC,
  title={Demonstration and characterization of the iron regulatory protein in human brain.},
  author={Jianming Hu and James R. Connor},
  journal={Journal of neurochemistry},
  year={1996},
  volume={67 2},
  pages={
          838-44
        }
}
Iron regulatory proteins (IRPs) are cytoplasmic RNA binding proteins that regulate expression of ferritin, erythroid 5-aminolevulinic acid synthase, and transferrin receptor through interaction with conserved RNA stem-loop structures called iron-responsive elements (IREs). Two IRPs (IRP1 and IRP2) have been reported. In the present study we provide evidence for and initial characterization of the IRPs in human brain. Two RNA-protein complexes were obtained by RNA band shift assay on cytoplasmic… CONTINUE READING
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