Demographic, clinical, and virological characteristics of hepatocellular carcinoma in Asia: Survey of 414 patients from four countries

  title={Demographic, clinical, and virological characteristics of hepatocellular carcinoma in Asia: Survey of 414 patients from four countries},
  author={Bao-en Wang and Wei-min Ma and Ali Sulaiman and Sjaifoellah Noer and Suwignyo Sumoharjo and Didacus Sumarsidi and Badri Nath Tandon and Kuniaki Nakao and Shunji Mishiro and Yuzo Miyakawa and Yoshihiro Akahane and Hiroshi Suzuki},
  journal={Journal of Medical Virology},
Demographic, etiological, clinical characteristics and treatment of hepatocellular carcinoma (HCC) were surveyed in 414 patients in Asia, including 107 from China, 15 from India, 101 from Indonesia and 191 from Japan. Males predominated in all countries, accounting for up to 75%. The mean ± SD age at the development of HCC was about 10 years older for the patients from Japan (63.8 ± 9.5, P < 0.001) and India (63.1 ± 11.2, P < 0.05) than those from China (54.0 ± 13.7) and Indonesia (53.7 ± 14.2… 
Multicenter epidemiologic study on hepatocellular carcinoma in Turkey.
The viral etiology (hepatitis B and hepatitis C infections) in the Turkish population was the most important factor in HCC development, with alcohol abuse as the third risk factor.
Epidemiology and survival of hepatocellular carcinoma in Turkey: outcome of multicenter study.
The viral etiology (hepatitis B and C infections) in Turkish population is found to be an important factor in HCC development and the Child-Pugh classification, AFP levels, TNM classification, being female and treatment were determined to be important prognostic factors in H CC patients.
Spectrum of hepatocellular carcinoma at Shifa International Hospital, Islamabad.
HCC has become a common tumour in Pakistan and studies are showing that this cancer is related to hepatitis C virus infection in majority of the patients, and a large number of them have underlying cirrhosis and are multifocal in origin and are presented in an advanced condition.
Evaluation of Clinical, Biochemical, Virological and Etiological Parameters in Patients of Hepatocellular Carcinoma: Experience from a Tertiary Care Center
There is dearth of data on clinical, biochemical, virological and etiological parameters in hepatocellular carcinoma (HCC) patients from India, and the association of viral load and tumor character is seen.
Hepatitis B virus infection in Indonesia.
A previous study conducted in Indonesia revealed that hepatic steatosis was associated with disease progression and drug resistance to lamivudine, which is prominent in Indonesia, remains obscure.
Hepatitis B as hepatocellular carcinoma (HCC) risk factor in the south region of Java, Indonesia
The study found that the age and hepatitis B infection have an association with the prevalence of HCC, and younger age was a protective factor against HCC.
Epidemiological Pattern of Hepatitis B and Hepatitis C as Etiological Agents for Hepatocellular Carcinoma in Iran and Worldwide
There is a need to improve the awareness about epidemiology of HBV and HCV infections, modes of transmission, and their complications, specifically HCC among population, and vaccination against HBV remains the most effective approach againstHBV infection with consequence decrease in HBV-related HCC.
Epidemiology of Hepatitis B, C, and E Viruses and Human Immunodeficiency Virus Infections in Tahuna, Sangihe-Talaud Archipelago, Indonesia
It seems that HCV and HIV have fortunately not made it as far as the Sangihe-Talaud Archipelago, although HBV infection remains a major problem in adults (with the HBsAg-positive rate at 4.9%), HB immunization has begun to protect the younger generation.


Epidemiology of Hepatitis B and C in China
Both HBsAg subtypes and HCV genotypes showed a region-dependent distribution, but with different patterns, and 20% of chronic liver disease patients were negative for both HBs Ag and HCv-RNA, indicating aregion-dependent prevalence of HCV but not HBV infection.
Association of hepatitis viruses with hepatocellular carcinoma in Thailand
It is confirmed that hepatitis B virus was associated with the development of hepatocellular carcinoma among the Thai population, among whom case histories of chronic hepatitis and cirrhosis have also been encountered quite frequently.
Maternal transmission of hepatitis B virus in childhood hepatocellular carcinoma
It is demonstrated that transmission of hepatitis B virus from the mothers during the perinatal period or early childhood is the most important mode of hepatitisB virus infection in HCC children in Taiwan.
Association between chronic hepatitis C infection and hepatocellular carcinoma in a Scottish population.
There is a strong association between chronic HCV infection, cirrhosis, and hepatocarcinogenesis in this Scottish population of patients presenting to a single hospital.
Interrelationship of blood transfusion, non‐A, non‐B hepatitis and hepatocellular carcinoma: Analysis by detection of antibody to hepatitis C virus
The slow, sequential progression from acute hepatitis C virus—related non‐A, non‐B hepatitis through chronic hepatitis and cirrhosis to hepatocellular carcinoma is suggested to support a causal association between hepatitis Cirus and hepato Cell carcinoma.
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The incidence of hepatocellular carcinoma increased significantly among younger persons (40 to 60 years old) during the period from 1991 to 1995 as compared with earlier periods, and the age-specific incidence of this cancer has progressively shifted toward younger people.
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  • Medicine, Biology
    The New England journal of medicine
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Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. Studies in percutaneous liver biopsies and post-mortem tissue specimens.
Rec recombinant-DNA technology and gel electrophoresis suggest that integration of HBV-DNA into hepatocytes occurs during the course of persistent HBV infection and precedes development of gross neoplasm.
The Scientific Challenge of Hepatitis C
Although to date no one has been able to grow HCV reliably in a laboratory culture of cells, on page 110, researchers describe a new system for culturing HCV9s RNA.