Demineralized bone matrix in bone repair: history and use.

  title={Demineralized bone matrix in bone repair: history and use.},
  author={Elliott Gruskin and Bruce A. Doll and F William Futrell and John P. Schmitz and Jeffrey O. Hollinger},
  journal={Advanced drug delivery reviews},
  volume={64 12},
Demineralized bone matrix (DBM) is an osteoconductive and osteoinductive commercial biomaterial and approved medical device used in bone defects with a long track record of clinical use in diverse forms. True to its name and as an acid-extracted organic matrix from human bone sources, DBM retains much of the proteinaceous components native to bone, with small amounts of calcium-based solids, inorganic phosphates and some trace cell debris. Many of DBM's proteinaceous components (e.g., growth… CONTINUE READING
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