Demethylation of somatic and testis-specific histone H2A and H2B genes in F9 embryonal carcinoma cells.

@article{Choi1993DemethylationOS,
  title={Demethylation of somatic and testis-specific histone H2A and H2B genes in F9 embryonal carcinoma cells.},
  author={Yong Chun Choi and C. B. Chae},
  journal={Molecular and cellular biology},
  year={1993},
  volume={13 9},
  pages={5538-48}
}
In contrast to many other genes containing a CpG island, the testis-specific H2B (TH2B) histone gene exhibits tissue-specific methylation patterns in correlation with gene activity. Characterization of the methylation patterns within a 20-kb segment containing the TH2A and TH2B genes in comparison with that in a somatic histone cluster revealed that: (i) the germ cell-specific unmethylated domain of the TH2A and TH2B genes is defined as a small region surrounding the CpG islands of the TH2A and… CONTINUE READING