Demethylation of RUNX3 by vincristine in colorectal adenocarcinoma cells.

Abstract

BACKGROUND Methylation-mediated inactivation of tumor-suppressor genes is a critical event during the pathogenesis of many malignancies. Vincristine is a conventional anticancer drug used to treat various types of cancers. However, few studies describe the epigenetic-based effects of vincristine. In this study, changes in the methylation of runt-related… (More)

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