Demethoxycurcumin and its semisynthetic analogues as antitubercular agents.


Demethoxycurcumin, isolated from the rhizomes of Curcuma longa, was found to possess antitubercular activity against Mycobacterium tuberculosis H (37)Rv strain at 200 microg/mL. Derivatisation of this active principle yielded a potent agent 6, exhibiting considerable activity with a minimum inhibitory concentration (MIC) value of 7.8 microg/mL. H (37)Rv:Mycobacterium tuberculosis H (37)Rv strain MIC:minimum inhibitory concentration.

DOI: 10.1055/s-0028-1088335

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@article{Agrawal2008DemethoxycurcuminAI, title={Demethoxycurcumin and its semisynthetic analogues as antitubercular agents.}, author={Dinesh Kumar Agrawal and Dharmendra Saikia and Richa Tiwari and Shweta Ojha and Karuna Shanker and Jonnala Kotesh Kumar and Anil Gupta and Sudeep Tandon and Arvind Singh Negi and Suman Preet Singh Khanuja}, journal={Planta medica}, year={2008}, volume={74 15}, pages={1828-31} }