Dementia, parkinsonism, and motor neuron disease: neurochemical and neuropathological correlates.

Abstract

The neurochemical markers for the major neurotransmitter systems were measured in the brain of a patient who died with a dementia-parkinsonism-motor neuron disease (DPMN) syndrome complex. Moderate neuronal loss in the substantia nigra, spongiform changes in the frontal cortex, and moderate anterior horn cell loss throughout the spinal cord were observed. A… (More)

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Cite this paper

@article{Gilbert1988DementiaPA, title={Dementia, parkinsonism, and motor neuron disease: neurochemical and neuropathological correlates.}, author={Jackie Gilbert and Stephen J. Kish and L J Chang and Caryl L. H. Morito and Kathleen Shannak and Oleh Hornykiewicz}, journal={Annals of neurology}, year={1988}, volume={24 5}, pages={688-91} }