Dementia: Cognitive resilience in APOE*ε4 carriers—is race important?


The apolipoprotein E ε4 (APOE*ε4) allele is among the most robust risk factors for cognitive decline, especially among people of European ancestry.1 The allele is more common among those of African ancestry, but has a smaller—though still important— relationship with cognitive decline in this population.2 Over the past few years, numerous other genomic, medical, psychological and experiential factors have been shown to influence cognitive decline.3 The extent to which these lifestyle factors can help maintain cognition among people at high genetic risk has important clinical and public health implications, and a recent paper by Kaup et al. has addressed this issue with an intriguing and unique study design.4

DOI: 10.1038/nrneurol.2015.38

Cite this paper

@article{Barnes2015DementiaCR, title={Dementia: Cognitive resilience in APOE*ε4 carriers—is race important?}, author={L. Barnes and David A. Bennett}, journal={Nature Reviews Neurology}, year={2015}, volume={11}, pages={190-191} }