Demarcation of Stable Subpopulations within the Pluripotent hESC Compartment

@inproceedings{Bhatia2013DemarcationOS,
  title={Demarcation of Stable Subpopulations within the Pluripotent hESC Compartment},
  author={Sonam Bhatia and Carlos Pilquil and Ivana Roth-Albin and Jonathan Draper},
  booktitle={PloS one},
  year={2013}
}
Heterogeneity is a feature of stem cell populations, resulting from innate cellular hierarchies that govern differentiation capability. How heterogeneity impacts human pluripotent stem cell populations is directly relevant to their efficacious use in regenerative medicine applications. The control of pluripotency is asserted by a core transcription factor network, of which Oct4 is a necessary member. In mouse embryonic stem cells (ESCs), the zinc finger transcription factor Rex1 (Zfp42) closely… CONTINUE READING
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