Delusions in frontotemporal lobar degeneration

Abstract

We assessed the significance and nature of delusions in frontotemporal lobar degeneration (FTLD), an important cause of young-onset dementia with prominent neuropsychiatric features that remain incompletely characterised. The case notes of all patients meeting diagnostic criteria for FTLD attending a tertiary level cognitive disorders clinic over a three year period were retrospectively reviewed and eight patients with a history of delusions were identified. All patients underwent detailed clinical and neuropsychological evaluation and brain MRI. The diagnosis was confirmed pathologically in two cases. The estimated prevalence of delusions was 14 %. Delusions were an early, prominent and persistent feature. They were phenomenologically diverse; however paranoid and somatic delusions were prominent. Behavioural variant FTLD was the most frequently associated clinical subtype and cerebral atrophy was bilateral or predominantly right-sided in most cases. We conclude that delusions may be a clinical issue in FTLD, and this should be explored further in future work.

DOI: 10.1007/s00415-009-0128-7

Extracted Key Phrases

1 Figure or Table

020406020102011201220132014201520162017
Citations per Year

144 Citations

Semantic Scholar estimates that this publication has 144 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Omar2009DelusionsIF, title={Delusions in frontotemporal lobar degeneration}, author={Rohani Omar and Elizabeth L . Sampson and Clement Loy and Catherine J. Mummery and Nick C. Fox and Martin Rossor and Jason D. Warren}, journal={Journal of Neurology}, year={2009}, volume={256}, pages={600 - 607} }