Delusional Disorder: Molecular Genetic Evidence for Dopamine Psychosis

  title={Delusional Disorder: Molecular Genetic Evidence for Dopamine Psychosis},
  author={Kiyoshi Morimoto and Ryosuke Miyatake and Mitsuo Nakamura and Takemi Watanabe and Toru Hirao and Hiroshi Suwaki},
Since delusional disorder is characterized by mono-symptomatic paranoid symptoms, it can be a good clinical model for investigating the dopaminergic mechanism responsible for paranoid symptoms. We examined neuroleptic responses, plasma homovanillic acid (pHVA) and genes of the dopamine receptor (DR) and its synthesizing enzyme (tyrosine hydroxylase: TH) in patients with delusional disorder and compared them with those of schizophrenic patients and healthy controls. Results: (1) A relatively… CONTINUE READING
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