Deltorphin II-induced rapid desensitization of delta-opioid receptor requires both phosphorylation and internalization of the receptor.

@article{Law2000DeltorphinIR,
  title={Deltorphin II-induced rapid desensitization of delta-opioid receptor requires both phosphorylation and internalization of the receptor.},
  author={Ping-Yee Law and Odile Maestri-El Kouhen and Jonathan Solberg and Wei Wang and Lennart Erickson and Horace H. Loh},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 41},
  pages={32057-65}
}
Similar to other G protein-coupled receptors, rapid phosphorylation of the delta-opioid receptor in the presence of agonist has been reported. Hence, agonist-induced desensitization of the delta-opioid receptor has been suggested to be via the receptor phosphorylation, arrestin-mediated pathway. However, due to the highly efficient coupling between the delta-opioid receptor and the adenylyl cyclase, the direct correlation between the rates of receptor phosphorylation and receptor… CONTINUE READING

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