Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis.

Abstract

Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis Wright (DZW), has shown high-cytotoxic activity in cancer cells. However, its mechanisms and in vivo anti-cancer effects remain unknown. In the present study, we evaluated the effects and explored the anti-tumor mechanisms of deltonin on a panel of colon cancer cell lines and in a mouse… (More)
DOI: 10.1159/000327949

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@article{Tong2011DeltoninAS, title={Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis.}, author={Qing-yi Tong and Yong Qing and D. -F. Shu and Yang Bo He and Ying-Lan Zhao and Yi Li and Zhen-ling Wang and Shi-yuan Zhang and Zhi-hua Xing and Cheng Xu and Yu-Quan Wei and Wen Huang and Xiao-hua Wu}, journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology}, year={2011}, volume={27 3-4}, pages={233-42} }